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Important open questions include whether most alternative splicing variants display distinct physiological functions and whether cell typerestricted regulatory factors orchestrate cell typespecific splicing decisions. With this issue of The EMBO Journal, Warzecha et al. (2010) uncover a network of alternative splicing changes resulting in epithelial transition (EMT), which happens to be controlled by downregulation from the Epithelial Splicing Regulatory Proteins 1 as well as (ESRP1 and ESRP2).
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