cheapbag214s
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Posted: Mon 16:10, 19 Aug 2013 Post subject: Acne antibiotic could alleviate symptoms of schizo |
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Acne antibiotic could alleviate the signs of schizophrenia,[link widoczny dla zalogowanych]
The research comes after a chance observation in Japan caused researchers to test the drug in patients with schizophrenia first in Japan itself,[link widoczny dla zalogowanych], and then all over the world.
Trials have already been locked in Israel,[link widoczny dla zalogowanych], Pakistan and Brazil where schizophrenic patients given the drug showed significant improvement.
Pre and post: The nation's Institute for Health Research will begin recruiting patients for any £1.9m UK trial of minocycline next month. Pictured,[link widoczny dla zalogowanych], a brain right after schizophrenia diagnosis (left) and five years later. - (Thanks to Paul Thompson/UCLA School of drugs)
Scientists believe schizophrenia along with other mental illnesses including depression and Alzheimer's may derive from inflammation within the brain,[link widoczny dla zalogowanych].
Minocycline has anti-inflammatory and neuroprotective effects that could account for the positive findings,[link widoczny dla zalogowanych].
The first account of the antibiotic's positive effects appeared in 2007,[link widoczny dla zalogowanych], when a 23-year-old Japanese man was admitted to hospital suffering from persecutory delusions and paranoid ideas.
The subject had no psychiatric background and blood tests and brain scans showed nothing unusual,[link widoczny dla zalogowanych].
He was going on halperidol a strong anti-psychotic drug,[link widoczny dla zalogowanych], however it had no effect. However when he developed severe pneumonia a week later and was prescribed the antibiotic the problem was cleared and also the psychosis resolved within 8 weeks.
However,[link widoczny dla zalogowanych], minocycline doesn't work as a cure.
Effective treatment,[link widoczny dla zalogowanych]? Minocycline has anti-inflammatory and neuroprotective effects
When the patient stopped taking the drug,[link widoczny dla zalogowanych], his psychiatric symptoms got worse again. But another treatment with minocyline made him better again.
The UK trial will recruit patients recently identified as having schizophrenia,[link widoczny dla zalogowanych], Jeremy Laurance,[link widoczny dla zalogowanych], an associate of the Schizophrenia Commission,[link widoczny dla zalogowanych], told The Independent.
Half the patients will take minocycline using their standard anti-psychotic treatment,[link widoczny dla zalogowanych], another half will take a placebo.
Brain scans is going to be completed in the beginnning and end from the year-long trial to check loss of grey matter which is an impact of schizophrenia,[link widoczny dla zalogowanych]. Tests will also measure inflammatory markers in the blood,[link widoczny dla zalogowanych].
Paul Jenkins,[link widoczny dla zalogowanych], CEO from the charity Rethink Mental Illness told MailOnline: 'We welcome the first promise shown by minocycline in treating psychosis in people with schizophrenia.
'Nowhere near plenty of time or money currently adopts to researching treatments for schizophrenia or other serious mental illnesses,[link widoczny dla zalogowanych], which cause pain and suffering for a lot of thousands of families over the UK.'
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